The following is the Jet Lag Study Abstract presented at the 48th International Congress of Aviation and Space Medicine on September 19, 2000.

Effects of ENADAlertâ Sublingual on JET LAG

Research Team:                                                          Gary Kay, Ph.D., Clinical Neuropsychologist, Georgetown University Medical Center, Washington, DC

Eric Virre, M.D., Ph.D., Center for Neurologic Study, La Jolla, CA

Jonathan B. Clark, M.D., M.P.H., Neurologist/Flight Surgeon, NASA, Houston, TX


Objective: A double-blind placebo controlled study observing thirty-five subjects who took an overnight flight from San Diego, CA to Washington, DC (Red eye). This study is designed to measure alertness, problem solving, response time, and executive functions in healthy adults who have crossed time zones and were sleep deprived.


Methods: Cognitive exams that were administered to the subjects are validated tests used by the FAA for pilot re-certification and by the United States Air Force. Exams are designed to measure subtle changes in alertness, memory and response time. Base line test conducted in San Diego in early afternoon were repeated in Washington the following morning and afternoon after travelling cross-country.


Results: The ENADAlertâ group showed a statistically significant improvement over the placebo group in 10 out of 14 tests. The study will be submitted for peer review publication in the Aviation Space and Environmental Medicine Journal. Anticipated acceptance in September 2000. Coverage was printed by Wall Street Journal on the front page on 29th November 2000.